Your best bet is to take the manfold off. If nyour going to drill it you need to stabilize it. if you try to drill the bit can wonder off and widen the hole out or drilling it out of position. Start with a small bit and work your way up. You have to look up what size drill to to use for the tap size. Also you'll need to figure out you depth.
The big issue will be drilling in the center of the bolt. Becareful when removing the manifold. It comes off in one piece and there are 2 hidden bolts by the center of the intake and exhaust manifold you can only see them fromm underneath.
Good luck Don